Transamidation of primary amides with amines catalyzed by zirconocene dichloride?

Chemical Communications Pub Date: 2012-10-22 DOI: 10.1039/C2CC37427G

Abstract

Zirconocene dichloride (Cp2ZrCl2) has been shown to be an effective catalyst for the transamidation of primary amides with amines in cyclohexane at 80 °C in 5–24 hours. For favourable substrates, the reaction can be performed at temperatures as low as 30 °C.

Graphical abstract: Transamidation of primary amides with amines catalyzed by zirconocene dichloride
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