Synthesis and testing of chromogenic phenoxazinone substrates for β-alanyl aminopeptidase?

Organic & Biomolecular Chemistry Pub Date: 2008-01-04 DOI: 10.1039/B716978G

Abstract

Novel 7-N-(β-alanyl)aminophenoxazin-3-one salts 27a–d have been synthesized and tested as chromogenic substrates for β-alanyl aminopeptidase, which is present in Pseudomonas aeruginosa, the most common respiratory pathogen in patients with cystic fibrosis. The biological results show that 7-N-(β-alanyl)amino-1-pentylphenoxazin-3-one trifluoroacetate salt27a is a chromogenic substrate for this bacterium, with a low degree of diffusion in nutrient media for growing bacterial cultures and a bright red colour, making it easily distinguishable from the agar background.

Graphical abstract: Synthesis and testing of chromogenic phenoxazinone substrates for β-alanyl aminopeptidase
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