Regioselective deoxygenative chalcogenation of 7-azindole N-oxides promoted by I2/PEG-200?
Organic & Biomolecular Chemistry Pub Date: 2019-11-11 DOI: 10.1039/C9OB02044F
Abstract
We developed a general and sustainable approach for the regioselective deoxygenative chalcogenation of 7-azindole N-oxides; the combination of an internal oxidant and a green solvent has been used successfully for the synthesis of mono- and dichalcogenyl 7-azaindoles which are of pharmaceutical interest. The regioselectivity is tunable by the variation of the reaction conditions. I2/PEG was established as an efficient and reusable catalytic system for C–H chalcogenation. This developed methodology has great potential for practical utility, with a broad substrate scope, green reaction conditions, and operational simplicity.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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