Regioselective copper-catalyzed chlorination and bromination of arenes with O2 as the oxidant?

Chemical Communications Pub Date: 2009-09-18 DOI: 10.1039/B915487F

Abstract

Electron-rich aromatic C–H bonds undergo regioselective chlorination and bromination in the presence of CuX2, LiX (X = Cl, Br) and molecular oxygen. Preliminary mechanistic insights suggest that the bromination and chlorination reactions proceed by different pathways.

Graphical abstract: Regioselective copper-catalyzed chlorination and bromination of arenes with O2 as the oxidant
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