Regioselective C–C cross-coupling of 1,2,4-thiadiazoles with maleimides through iridium-catalyzed C–H activation?

Organic & Biomolecular Chemistry Pub Date: 2019-07-29 DOI: 10.1039/C9OB01539F

Abstract

A regioselective C–C cross-coupling of 1,2,4-thiadiazoles with maleimides through iridium catalysis was developed. This transformation tactically linked the 1,2,4-thiadiazoles and succinimides together, and the novel molecules formed may have potential biological activity.

Graphical abstract: Regioselective C–C cross-coupling of 1,2,4-thiadiazoles with maleimides through iridium-catalyzed C–H activation
Recommended Literature