Regioselective 5-exo-dig oxy-cyclization of 2-alkynylbenzamide for the synthesis of isobenzofuran-1-imines and isobenzofuran?
Organic & Biomolecular Chemistry Pub Date: 2018-05-31 DOI: 10.1039/C8OB00779A
Abstract
A TBAB-mediated brominative 5-exo-dig oxy-cyclization of 2-alkynylbenzamide is described here for the synthesis of isobenzofuran-1-imines and isobenzofuran derivatives at room temperature with a high efficiency and a broad reaction scope. The resulting isobenzofuran derivatives are also applied for synthesising various substituted isobenzofuran derivatives.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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