Silver salts and DBU cooperatively catalyzed nucleophilic addition/cyclization of propargylic alcohols with trifluoromethyl ketones?
Organic & Biomolecular Chemistry Pub Date: 2015-04-10 DOI: 10.1039/C5OB00438A
Abstract
A general and efficient synthesis of trifluoromethyl substituted 5-alkylidene-1,3-dioxolane using a silver salt and DBU cooperatively catalyzed nucleophilic addition/cyclization of propargylic alcohols and trifluoromethyl ketones is described. The procedure produced 5-alkylidene-1,3-dioxolane derivatives with good to excellent yields and can be used with a broad range of substrates.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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