Synthesis and immunochemical evaluation of a novel Neisseria meningitidis serogroup A tetrasaccharide and its conjugate?
Organic Chemistry Frontiers Pub Date: 2017-08-15 DOI: 10.1039/C7QO00468K
Abstract
A tetrameric repeating unit of capsular polysaccharide (CPS) of Neisseria meningitidis A (MenA) containing phosphodiester α-(1→6) linkages between N-acetyl-3-O-acetyl-D-mannosamine moieties was synthesized with excellent yield using stereoselective glycosyl phosphorylation strategy. The synthesized tetrasaccharide was conjugated with tetanus toxoid protein (TT) to furnish a glycoconjugate derivative in satisfactory yield. The immunochemical properties of the tetrasaccharide and semi-synthetic glycoconjugate derivative were evaluated for the development of a potential MenA vaccine candidate.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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