A simple method for the α-oxygenation of aldehydes

Chemical Communications Pub Date: 2005-01-24 DOI: 10.1039/B418101H

Abstract

A mild, efficient and general method for the chemospecific α-oxygenation of aldehydes is described. Treatment of a series of aldehydes with N-tert-butyl-O-benzoyl hydroxylamine hydrochloride gives the corresponding α-oxygenated carbonyl via a proposed pericyclic rearrangement process.

Graphical abstract: A simple method for the α-oxygenation of aldehydes
Recommended Literature