TBHP/I2-promoted oxidative coupling of acetophenones with amines at room temperature under metal-free and solvent-free conditions for the synthesis of α-ketoamides?

Green Chemistry Pub Date: 2012-05-28 DOI: 10.1039/C2GC35489F

Abstract

A novel and efficient TBHP/I2-promoted oxidative coupling reaction of acetophenones with amines for the synthesis of α-ketoamides has been developed. The reactions proceeded smoothly at room temperature under metal-free and solvent-free conditions and generated the corresponding products in good yields.

Graphical abstract: TBHP/I2-promoted oxidative coupling of acetophenones with amines at room temperature under metal-free and solvent-free conditions for the synthesis of α-ketoamides
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