Sensitive fluorescence biosensor for folate receptor based on terminal protection of small-molecule-linked DNA?

Chemical Communications Pub Date: 2012-04-30 DOI: 10.1039/C2CC31979A

Abstract

Based on the specific folic acid–folate receptor (FA–FR) interaction, macromolecular FR can bind with FA-linked DNA–small molecule chimeras, which can prevent enzymolysis by exonuclease III (Exo III), enabling a novel fluorescence biosensor for FR to be developed using quinaldine red as a G-quadruplex-binding probe.

Graphical abstract: Sensitive fluorescence biosensor for folate receptor based on terminal protection of small-molecule-linked DNA
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