Recent advances in transition metal-catalyzed reactions of carbamoyl chlorides
Organic Chemistry Frontiers Pub Date: 2021-04-19 DOI: 10.1039/D0QO01648A
Abstract
The development of carbamoyl chlorides as synthons for various amide-containing molecules and heterocycles has been summarized and discussed in this review article. Carbamoyl chlorides can participate in a diverse range of transition metal-catalyzed transformations including radical initiated reactions and cross-coupling and annulation reaction modes as well as C–H functionalization to access amide-functionalized organic frameworks having extensive applications in pharmaceutical and natural product synthesis. This review mainly highlights the advancements of carbamoyl chlorides as a powerful synthetic tool in transition-metal catalyzed reactions over the last two decades. In addition, transition-metal catalyzed reactions of their corresponding structural analogs, carbamoyl fluorides and cyanides, with respect to their chemical behavior are also briefly reviewed.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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