Syntheis and structure of cis-peptidyl prolinamide mimetics based upon 1,2,5-triazepine-3,6-diones
Chemical Communications Pub Date: 1900-01-01 DOI: 10.1039/CC9960000085
Abstract
The synthesis of novel constrained cis-peptidyl prolinamide mimetics for the dipeptide amides glycyl (2S)-prolinamide, (2S)-alanyl (2S)-prolinamide and (2R)-alanyl (2S) prolinamide and some analogues, based upon fused 1,2,5-triazepine-3,6-diones, is described; these are suitable for elaboration into larger peptides at both the carboxy and amino termini, X-ray crystal structures for some of the compounds and intermediates are also presented.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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