The thioamidation of gem-dibromoalkenes in an aqueous medium?
Organic & Biomolecular Chemistry Pub Date: 2021-02-18 DOI: 10.1039/D0OB02319A
Abstract
The direct integration of sulphur and amine groups with 1,1-dibromoalkenes for thioamide synthesis has been achieved in an aqueous medium. The presented green protocol emphasizes the suitability of aqueous media for the thioamidation reaction and enables greater selectivity with synthetic utility. A wide range of thioamides in moderate to excellent yields has been achieved using readily available starting materials, with the use of no organic solvents, catalysts, or additives.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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