A Weinreb amide approach to the synthesis of trifluoromethylketones?

Chemical Communications Pub Date: 2012-08-09 DOI: 10.1039/C2CC35037H

Abstract

A novel route to access trifluoromethylketones (TFMKs) from Weinreb amides is reported. This represents the first documented case of the Ruppert–Prakash reagent (TMS–CF3) reacting in a constructive manner with an amide and enables synthesis of TMFKs without risk of over-trifluoromethylation.

Graphical abstract: A Weinreb amide approach to the synthesis of trifluoromethylketones
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