Access to 5H-benzo[a]carbazol-6-ols and benzo[6,7]cyclohepta[1,2-b]indol-6-ols via rhodium-catalyzed C–H activation/carbenoid insertion/aldol-type cyclization?
Organic Chemistry Frontiers Pub Date: 2020-08-27 DOI: 10.1039/D0QO00820F
Abstract
The rhodium-catalyzed mono-ortho C–H activation/carbenoid insertion/aldol-type cyclization of 3-aldehyde-2-phenyl-1H-indoles with diazo compounds has been developed. This method provides a novel approach to 5H-benzo[a]carbazol-6-ols and benzo[6,7]cyclohepta[1,2-b]indol-6-ols with a broad range of substrate scope in an air atmosphere. In addition, the synthetic potentialities of the developed approach are demonstrated by gram scale and versatile late-stage transformations.
![Graphical abstract: Access to 5H-benzo[a]carbazol-6-ols and benzo[6,7]cyclohepta[1,2-b]indol-6-ols via rhodium-catalyzed C–H activation/carbenoid insertion/aldol-type cyclization](http://scimg.chem960.com/usr/1/D0QO00820F.jpg)
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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