Selective hydrogenation of primary amides and cyclic di-peptides under Ru-catalysis?

Chemical Communications Pub Date: 2020-08-26 DOI: 10.1039/D0CC04550K

Abstract

A ruthenium(II)-catalyzed selective hydrogenation of challenging primary amides and cyclic di-peptides to their corresponding primary alcohols and amino alcohols, respectively, is reported. The hydrogenation reaction operates under mild and eco-benign conditions and can be scaled-up.

Graphical abstract: Selective hydrogenation of primary amides and cyclic di-peptides under Ru-catalysis
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