Synthesis of trifluoromethylated pyrazolidines by [3 + 2] cycloaddition?
Organic & Biomolecular Chemistry Pub Date: 2017-07-04 DOI: 10.1039/C7OB01299C
Abstract
A highly efficient [3 + 2] cycloaddition between trifluoromethylated N-acylhydrazones and nitroolefins in the presence of potassium hydroxide under phase transfer catalysis is developed to afford potentially bioactive trifluoromethylated pyrazolidines, which can be further transformed into trifluoromethylated pyrazoles in good yields.
![Graphical abstract: Synthesis of trifluoromethylated pyrazolidines by [3 + 2] cycloaddition](http://scimg.chem960.com/usr/1/C7OB01299C.jpg)
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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