Selective direct C–H polyfluoroarylation of electron-deficient N-heterocyclic compounds?
Organic Chemistry Frontiers Pub Date: 2020-10-12 DOI: 10.1039/D0QO00923G
Abstract
The first C2-selective direct C–H polyfluoroarylation of electron-deficient N-heterocycles with polyfluorobenzoic acid via the decarboxylative arylation process was achieved by using CuBr2 as the mediator in the green solvent diglyme. The key to success is using the N-methylation activation strategy and TBAB as an important additive. The protocol features broad substrate scope, ligand- and base-free conditions, and good functional group compatibility, and offers a powerful synthetic tool for assembling various polyfluoroarylated N-heterocycles.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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