Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis?
Chemical Communications Pub Date: 2004-09-24 DOI: 10.1039/B411973H
Abstract
PCR primers designed to selectively amplify the unique C-methyltransferase domain of fungal polyketide synthases were used to selectively clone a polyketide synthase gene involved in the biosynthesis of the squalene synthase inhibitor squalestatin S1 1, heterologous expression of which led to the biosynthesis of the squalestatin side-chain.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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