Selective cleavage of 3,5-bis-(trifluoromethyl)benzylcarbamate by SmI2–Et3N–H2O?

Chemical Communications Pub Date: 2013-06-06 DOI: 10.1039/C3CC41642A

Abstract

A novel electron poor protection group for amines has been developed. It undergoes rapid cleavage by SmI2–Et3N–H2O and its orthogonality towards the regular benzyl carbamate group (CBz) under reductive or transfer hydrogenolytic conditions is reported.

Graphical abstract: Selective cleavage of 3,5-bis-(trifluoromethyl)benzylcarbamate by SmI2–Et3N–H2O
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