Synthesis of novel guanidine-based ABA triblock copolymers and their antimicrobial honeycomb films?

Polymer Chemistry Pub Date: 2018-06-26 DOI: 10.1039/C8PY00732B

Abstract

Novel amphiphilic poly(methacryl guanidine hydrochloride)-block-polystyrene-block-poly(methacryl guanidine hydrochloride) (PMAGH-b-PS-b-PMAGH) ABA triblock copolymers with a controlled molecular weight and composition were synthesized via sequential reversible addition/fragmentation chain transfer (RAFT) polymerization of methacryl guanidine hydrochloride (MAGH) and styrene, using S,S′-bis (α,α′-dimethyl-α′′-acetic acid) trithiocarbonate (BDATC) as the initial chain transfer agent. Highly ordered honeycomb films of PMAGH-b-PS-b-PMAGH were fabricated via a facile and versatile static breath-figure process. PMAGHs and the honeycomb films of PMAGH-b-PS-b-PMAGH showed high antimicrobial activity against Escherichia coli (E. coli) and Bacillus subtilis (B. subtilis). The minimum MIC values of PMAGHs are 113 μg mL?1 for E.coli and 450 μg mL?1 for B. subtilis. PMAGH-b-PS-b-PMAGH honeycomb films inhibited 61% of E. coli and 92% of B. subtilis.

Graphical abstract: Synthesis of novel guanidine-based ABA triblock copolymers and their antimicrobial honeycomb films
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