The influence of additives on orthogonal reaction pathways in the Mizoroki–Heck arylation of vinyl ethers?
Reaction Chemistry & Engineering Pub Date: 2021-04-30 DOI: 10.1039/D1RE00124H
Abstract
The Mizoroki–Heck arylation of electron-rich alkenes such as butyl vinyl ether often results in regioisomeric mixtures of products under typical reaction conditions. To discover new catalytic systems for achieving α-selective arylation, an alternative approach to generating aryl methyl ketones, we have combined microscale high-throughput experimentation with mechanistic studies on a model system. A specific combination of catalyst, solvent, base, and additives was found to be crucial for both activity and selectivity, especially when translating screening hits into preparative-scale synthesis.
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Journal Name：Reaction Chemistry & Engineering
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CAS no.: 89640-58-4
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