Cobalt-catalyzed regioselective hydrohydrazination of epoxides?
Organic & Biomolecular Chemistry Pub Date: 2020-02-03 DOI: 10.1039/D0OB00037J
Abstract
Using an air-stable cobalt catalyst [Cp*Co(1,2-Ph2PC6H4S)(NCMe)]BF4 (1, Cp* = Me5C5?), we have achieved catalytic regioselective hydrohydrazination of epoxides to 1,1-hydrazinoalcohols in an atom-economical manner. The catalysis involves a cobalt–hydrazine intermediate, in which the NH2 group of the hydrazine binds to the metal center, inhibiting its nucleophilic reactivity and allowing the NH group to participate in the regioselective hydrohydrazination.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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