Pyridylacetic acids and related systems as alkylheteroarene surrogates in asymmetric decarboxylative Michael addition?
Chemical Communications Pub Date: 2021-03-01 DOI: 10.1039/D0CC08182E
Abstract
In this manuscript, a novel method for the preparation of enantiomerically enriched pyridine derivatives has been described. It is based on the utilization of readily available 2-pyridylacetic acids as valuable synthons for the introduction of a pyridine ring in an asymmetric fashion. They have been used as pronucleophiles in asymmetric decarboxylative Michael addition to α,β-unsaturated aldehydes. The synthesis based on iminium activation using a chiral aminocatalyst that controlled the stereochemical outcome of the transformation has been successfully accomplished.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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