Synthesis of 5,5-difluoro-5-phosphono-pent-2-en-1-yl nucleosides as potential antiviral agents?
RSC Advances Pub Date: 2017-06-23 DOI: 10.1039/C7RA05153K
Abstract
A series of hitherto unknown acyclic 5,5-difluoro-5-phosphono-pent-2-en-1-yl-pyrimidines (9a, b, 13a, b), -purines (16a, b) and -(1,2,4)-triazolo-3-carboxamide (19) were successfully synthesized from (E)-1-bromo-5-diethoxyphosphoryl-5,5-difluoro-pent-2-ene in a stereoselective manner. All the synthetized compounds were assayed for antiviral activity against various viruses, but were found to be neither active nor toxic.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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