Rapid polymorph screening on milligram quantities of pharmaceutical material using phonon-mode Raman spectroscopy?

CrystEngComm Pub Date: 2009-11-09 DOI: 10.1039/B921114B

Abstract

We demonstrate that screening of pharmaceutical compounds for polymorphism can be rapidly achieved for milligram quantities of material using in situ phonon-mode Raman spectroscopy, and suggest that phonon-mode Raman spectra (10–400 cm?1) can be used as “polymorphic fingerprints”.

Graphical abstract: Rapid polymorph screening on milligram quantities of pharmaceutical material using phonon-mode Raman spectroscopy
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