Synthesis and characterization of a ZnMn2O4 nanostructure as a chemical nanosensor: a facile and new approach for colorimetric determination of omeprazole and lansoprazole drugs

RSC Advances Pub Date: 2017-09-11 DOI: 10.1039/C7RA08010G

Abstract

We have developed a facile method for preparation of ZnMn2O4 nanostructures via an auto-combustion method using various fuels: urea, glycine and L-alanine. The type of fuel and pH of the combustion media have a significant effect on the combustion products. Glycine fuel generated spinel ZnMn2O4 on combustion, and calcination of the sample produced pure spinel ZnMn2O4 nanoparticles with an average crystallite size of 19 nm. Whereas, other fuels generated multiphase compounds on combustion. The products were elucidated by means of XRD, FE-SEM, EDS, TEM, FT-IR, and UV-Vis diffuse reflectance spectra. The as-fabricated product was applied to construct a novel chemical nanosensor for the determination of omeprazole and lansoprazole drugs. Different factors influencing the colorimetric determination of the drugs were examined such as contact time, temperature, initial drug concentration, and ZnMn2O4 dose. The proposed chemical nanosensor revealed high sensitivity, low detection limit, and a relatively wide linear range (0.80–8.0 and 0.80–8.8 μg mL?1 at λmax 454 nm for omeprazole and lansoprazole, respectively).

Graphical abstract: Synthesis and characterization of a ZnMn2O4 nanostructure as a chemical nanosensor: a facile and new approach for colorimetric determination of omeprazole and lansoprazole drugs
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