Spiroketals via oxidative rearrangement of enol ethers?

Organic & Biomolecular Chemistry Pub Date: 2006-11-14 DOI: 10.1039/B612992G

Abstract

Oxidative rearrangement of cyclic enol ethers leads to α-alkoxyesters. In the presence of a neighboring spiroether, this approach provides a stereoselective access to spiroketals. A modified proposal for the biosynthesis of acutumine is presented.

Graphical abstract: Spiroketals via oxidative rearrangement of enol ethers
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