Tandem hydroformylation–hydrazone formation–Fischer indole synthesis: a novel approach to tryptamides?

Organic & Biomolecular Chemistry Pub Date: 2005-05-20 DOI: 10.1039/B503396A

Abstract

A novel one-pot synthesis of indole systems via tandem hydroformylationhydrazone formation–Fischer indolization starting from allylic amides and aryl hydrazines is described. This tandem procedure directly leads to biologically interesting tryptamides and analogues.

Graphical abstract: Tandem hydroformylation–hydrazone formation–Fischer indole synthesis: a novel approach to tryptamides
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