Practical preparation of diphenylmethyl ethers from 2-diphenylmethoxypyridine using catalytic iron(iii) chloride?

Organic & Biomolecular Chemistry Pub Date: 2019-06-05 DOI: 10.1039/C9OB01093A

Abstract

A novel facile synthetic method for producing diphenylmethyl (DPM) ethers from 2-diphenylmethoxypyridine was developed. A variety of DPM ethers was successfully achieved with high yield via treatment of alcohols with 2-diphenylmethoxypyridine in the presence of catalytic FeCl3. The procedure is a practical and efficient synthetic procedure to protect various alcohols, and it can be applied to prepare bioactive compounds.

Graphical abstract: Practical preparation of diphenylmethyl ethers from 2-diphenylmethoxypyridine using catalytic iron(iii) chloride
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