Structure, bioactivities, biosynthetic relationships and chemical synthesis of the spirodioxynaphthalenes?

Natural Product Reports Pub Date: 2010-11-01 DOI: 10.1039/C0NP00031K

Abstract

Covering: 1989 to September 2010

The spirodioxynaphthalenes are a group of fungal secondary metabolites, consisting of a 1,8-dihydroxynaphthalene-derived spiroketal unit linked to a second oxidized naphthalene moiety, that show a great variety of biological activities. This review summarizes the research on the isolation, structure elucidation, biological activities, biosynthesis, and chemical synthesis of the spirodioxynaphthalenes published over the last 20 years. More than 100 fungal and plant metabolites are described, and over 100 references cited.

Graphical abstract: Structure, bioactivities, biosynthetic relationships and chemical synthesis of the spirodioxynaphthalenes
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