Polymorphism in phenobarbital: discovery of a new polymorph and crystal structure of elusive form V?

Chemical Communications Pub Date: 2016-02-25 DOI: 10.1039/C6CC00959J

Abstract

This report highlights the discovery of a new polymorph of the anticonvulsant drug phenobarbital (PB) using polymer-induced heteronucleation (PIHn) and unravelling the crystal structure of the elusive form V. Both forms are characterized by structural, thermal and VT-Raman spectroscopy methods to elucidate phase transformation behavior and shed light on stability relationships.

Graphical abstract: Polymorphism in phenobarbital: discovery of a new polymorph and crystal structure of elusive form V
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