Synthesis of N-alkylated 2-pyridones through Pummerer type reactions of activated sulfoxides and 2-fluoropyridine derivatives?
Organic & Biomolecular Chemistry Pub Date: 2018-05-14 DOI: 10.1039/C8OB00860D
Abstract
N-Alkylated 2-pyridone products were obtained in good to excellent yields through a one-pot procedure involving either normal or interrupted Pummerer reactions between triflic anhydride activated sulfoxides and 2-fluoropyridine derivatives, followed by hydrolysis. This is a rare case that uses 2-fluoropyridine as a nucleophile in Pummerer type reactions.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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