Ravynic acid, an antibiotic polyeneyne tetramic acid from Penicillium sp. elucidated through synthesis?
Organic & Biomolecular Chemistry Pub Date: 2016-07-21 DOI: 10.1039/C6OB00938G
Abstract
A new antibiotic natural product, ravynic acid, has been isolated from a Penicillium sp. of fungus, collected from Ravensbourne National Park. The 3-acylpolyenyne tetramic acid structure was definitively elucidated via synthesis. Highlights of the synthetic method include the heat induced formation of the 3-acylphosphorane tetramic acid and a selective Wittig cross-coupling to efficiently prepare the natural compounds carbon skeleton. The natural compound was shown to inhibit the growth of Staphylococcus aureus down to concentrations of 2.5 μg mL?1.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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