A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids?

Chemical Communications Pub Date: 2015-05-11 DOI: 10.1039/C5CC03002A

Abstract

A powerful strategy for the efficient lead-oriented synthesis of novel molecular scaffolds is demonstrated. Twenty two scaffolds were prepared from just four α-amino acid-derived building blocks and a toolkit of six connective reactions. Importantly, each individual scaffold has the ability to specifically target lead-like chemical space.

Graphical abstract: A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids
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