Synthesis of (?)-epibatidine?
RSC Advances Pub Date: 2014-02-10 DOI: 10.1039/C4RA00770K
Abstract
An asymmetric synthesis to the dendrobatid alkaloid (?)-epibatidine has been described, featuring chiral resolution of both optically pure 7-azabicyclo[2.2.1]heptanecarboxylic acid, and subsequent transformations to (?)-epibatidine. The methodology provides a flexible access to various substituted chiral epibatidine analogues.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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