Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues?
Organic & Biomolecular Chemistry Pub Date: 2010-01-25 DOI: 10.1039/B922442D
Abstract
Enantioenriched tetrafluorinated aryl-C-nucleosides were synthesised in four steps from 1-benzyloxy-4-bromo-3,3,4,4-tetrafluorobutan-2-ol. The presence of the tetrafluorinated ethylene group is compatible with O-phosphorylation of the primary alcohol, as demonstrated by the successful preparation of the tetrafluorinated naphthyl-C-nucleotide.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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