RANEY? nickel-catalyzed reductive N-methylation of amines with paraformaldehyde: theoretical and experimental study?

RSC Advances Pub Date: 2014-08-29 DOI: 10.1039/C4RA04414B

Abstract

RANEY? Ni-catalyzed reductive N-methylation of amines with paraformaldehyde has been investigated. This reaction proceeds in high yield with water as a byproduct. RANEY? Ni can be easily recovered and reused with a slight decrease of the yield. Using density functional theory (DFT), the mechanism of RANEY? Ni-catalyzed reductive N-methylation is discussed in detail. The reaction pathway involves the addition of amine with formaldehyde, dehydration to form the imine and hydrogenation. In the transition state of hemiaminal dehydration, the C–O bond cleavage of the aromatic amine is more difficult than that of the aliphatic amine. For the aromatic amine, a higher energy barrier must be overcome, which results in a relatively low yield. After addition of amine with formaldehyde and dehydration, imine is obtained and preferred to adsorb on the bridge site of the Ni(111) surface. The preferential pathways of imine hydrogenation involve the pre-adsorbed hydrogen atom attacking the nitrogen atom of the imine. The energy barrier of hydrogenation is much lower than that of addition and dehydration. Thus, the hydrogenation of imine is a relatively rapid reaction step. In the reductive N-methylation of secondary amine, the possible dehydration pathway is different from the one of the primary amine. In the dehydration of the secondary amine, the intermediate hemiaminal is initially adsorbed on the bridge site of the Ni(111) surface, then undergoes C–O bond cleavage, and eventually the hydroxyl is located in the bridge site. With the final hydrogenation, the product is obtained by adsorption on the top site of the Ni(111) surface.

Graphical abstract: RANEY? nickel-catalyzed reductive N-methylation of amines with paraformaldehyde: theoretical and experimental study
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