Switching stereoselectivity in rhodium-catalysed 1,4-additions: the asymmetric synthesis of 2-substituted pyrrolizidinones?

Chemical Communications Pub Date: 2006-10-03 DOI: 10.1039/B610128C

Abstract

The appropriate choice of organometallic nucleophile enables the straightforward preparation of different stereoisomers of 2-substituted pyrrolizidinones utilising the rhodium-catalysed 1,4-addition reaction.

Graphical abstract: Switching stereoselectivity in rhodium-catalysed 1,4-additions: the asymmetric synthesis of 2-substituted pyrrolizidinones
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