A short and modular approach towards 3,5-disubstituted indolizidine alkaloids?
Organic & Biomolecular Chemistry Pub Date: 2016-06-28 DOI: 10.1039/C6OB01308B
Abstract
3,5-Dialkyl indolizidines have been prepared in four linear steps from commercially available starting materials. The sequence involves two direct α-functionalization steps and a subsequent reductive amination and provides diastereoselective access to both C-3 epimers of the 5,9-trans-substituted indolizines. The naturally occurring indolizidines 195B and 223AB have been synthesized using this methodology.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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