Simple and efficient syntheses of 2-hydroxy-3H-phenoxazin-3-ones by aerobic oxidative cross-cyclocondensation in water?

Green Chemistry Pub Date: 2021-01-12 DOI: 10.1039/D0GC03861J

Abstract

A novel, simple and versatile synthetic approach that utilized natural renewable low-toxic gallic acid as an organocatalyst was developed for efficient aerobic oxidative cross-cyclocondensations of equimolar 2-aminophenols and 2-hydroxylphenols to afford various 2-hydroxy-phenoxazin-3-ones with moderate to high isolated yields at room temperature in water.

Graphical abstract: Simple and efficient syntheses of 2-hydroxy-3H-phenoxazin-3-ones by aerobic oxidative cross-cyclocondensation in water
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