Stereospecific synthetic approach towards Tamiflu using the Ramberg–Backlund reaction from cysteine hydrochloride?
RSC Advances Pub Date: 2014-11-18 DOI: 10.1039/C4RA10391B
Abstract
The stereospecific formal synthesis of Tamiflu from L-cysteine hydrochloride as the chiral source is described. The notable feature of the present strategy is the Ramberg–Backlund reaction and Sharpless–Reich protocol as the key chemical transformations to access the cyclohexene skeleton of Tamiflu.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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