Removing the superfluous: a supported squaramide catalyst with a minimalistic linker applied to the enantioselective flow synthesis of pyranonaphthoquinones?
Catalysis Science & Technology Pub Date: 2016-03-21 DOI: 10.1039/C6CY00473C
Abstract
A continuous flow setup has been implemented for the enantioselective production of a library of pyranonaphthoquinones. This was possible through a sequential two-step process involving a squaramide-catalyzed Michael reaction and oxa-Michael cyclization. A key factor for the success of this methodology was the development of a new, cost-effective polystyrene-supported squaramide.
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Journal Name：Catalysis Science & Technology
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CAS no.: 89640-58-4
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