Pot, atom and step economic synthesis: a diversity-oriented approach to construct 2-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones?

RSC Advances Pub Date: 2013-02-28 DOI: 10.1039/C3RA22909B

Abstract

A diversity-oriented approach to construct 2-heteroaryl-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one derivatives via copper-promoted two-step one pot reactions from chromenone derivatives has been developed. Pot, atom and step economy (PASE) were combined in these sequential reactions, and at least six bonds were formed in one pot. A number of drug-like small molecules were prepared quickly and efficiently.

Graphical abstract: Pot, atom and step economic synthesis: a diversity-oriented approach to construct 2-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones
Recommended Literature