Palladium-catalyzed and alcohol-enabled transformation to synthesize benzocyclic ketones?
Organic & Biomolecular Chemistry Pub Date: 2021-11-12 DOI: 10.1039/D1OB01996A
Abstract
Catalytic carbonyl formation ranks as one of the most important synthetic methodologies. Herein, a highly effective palladium-catalyzed and alcohol-promoted transformation of nitriles to synthesize benzocyclic ketones is described. It provides a straightforward access to potentially valuable indanone compounds in high yields in the presence of alcohol. It avoided the usage of carbon monoxide or an additional hydrolysis procedure.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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