Palladium-catalyzed allylation of tautomerizable heterocycles with alkynes?

Organic & Biomolecular Chemistry Pub Date: 2017-06-19 DOI: 10.1039/C7OB01119A

Abstract

A method for the allylic amidation of tautomerizable heterocycles was developed by a palladium catalyzed allylation reaction with 100% atom economy. A series of structurally diverse N-allylic substituted heterocycles can be synthesized in good yields with high chemo-, regio-, and stereoselectivities under mild conditions.

Graphical abstract: Palladium-catalyzed allylation of tautomerizable heterocycles with alkynes
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