ortho-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3H)-ones: a convergent synthetic route to bouchardatine and sildenafil?
RSC Advances Pub Date: 2020-08-21 DOI: 10.1039/D0RA06820A
Abstract
A facile access to fused pyrimidin-4(3H)-one derivatives has been established by using the metal-free ortho-naphthoquinone-catalyzed aerobic cross-coupling reactions of amines. The utilization of two readily available amines allowed a direct coupling strategy to quinazolinone natural product, bouchardatine, as well as sildenafil (Viagra?) in a highly convergent manner.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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