Solid phase strain promoted “click” modification of DNAvia[3+2]-nitrile oxide–cyclooctyne cycloadditions?

Chemical Communications Pub Date: 2010-12-21 DOI: 10.1039/C0CC03985C

Abstract

Rapid, catalyst free, solid phase modification of DNA by strain promoted cyclooctyne–nitrile oxide click chemistry is reported; the reaction is characterised by mild conditions, occurring in an aqueous environment under atmospheric conditions at room temperature and is complete in 10 minutes.

Graphical abstract: Solid phase strain promoted “click” modification of DNAvia[3+2]-nitrile oxide–cyclooctyne cycloadditions
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