Organocatalytic oxidation of aldehydes to mixed anhydrides??

Chemical Communications Pub Date: 2012-08-31 DOI: 10.1039/C2CC35220F

Abstract

TEMPO catalyzes the direct oxidation of aldehydes to mixed anhydrides in the presence of a carboxylic acid. The anhydrides can be converted in situ to esters, secondary, tertiary or Weinreb amides in high yield. Oxidation of the aldehyde directly to 2-propyl esters is also possible using only catalytic amounts of acid. The oxidation reactions are rapid and take place under mild conditions.

Graphical abstract: Organocatalytic oxidation of aldehydes to mixed anhydrides
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